The term CITY IN THE TEXAS PANHANDLE is solved by the 8-letter word Amarillo. Amarillo is a city located in the northern part of the state of Texas, in the Texas Panhandle region. It is the 14th most populous city in the state and the largest city in the Texas Panhandle. Amarillo is known for its cultural attractions, such as the Amarillo Zoo, the Amarillo Museum of Art, and the Don Harrington Discovery Center.