The term CITY IN SW CALIFORNIA can be summarized by four crossword solutions: Irvine (6 letters), BREA (4 letters), Eastla (6 letters), and Santa Maria (10 letters). Irvine is a city located in Orange County, California, and is home to the University of California, Irvine. BREA is a city located in Orange County, California, and is known for its oil production. Eastla is an unincorporated community located in Los Angeles County, California. Santa Maria is a city located in Santa Barbara County, California, and is known for its wine production.