The city of Reno is a 4-letter solution to the crossword term 'City by Lake Tahoe'. Reno is the largest city in the state of Nevada and is located in the western part of the United States. It is situated in a high desert at the foot of the Sierra Nevada mountain range, and is just 22 miles from Lake Tahoe. Reno is known for its casinos, entertainment, and outdoor activities, and is a popular tourist destination.