The crossword solution for the term 'Change the Essence of' is DENATURE, which is an 8-letter word. DENATURE is a process in which the chemical or physical properties of a substance are changed, usually by adding another substance. This process is often used to make a substance less toxic or more stable. DENATURE can also refer to the process of changing the essential nature of something, such as altering the flavor of a food or changing the structure of a protein.