The term 'CENTER OF RENAISSANCE ART' can be answered with the five-letter word 'ITALY'. Italy was a major center of Renaissance art during the 14th to 16th centuries, with cities such as Florence and Rome becoming renowned for their art and architecture. During this period, Italy was home to some of the most influential artists in history, including Michelangelo, Leonardo da Vinci, and Raphael. These artists helped to shape the course of Western art and culture, and their works remain some of the most iconic pieces of art in the world.