The crossword solution for the term CENTER OF NYC is YORK. York is a city in North Yorkshire, England, and is the traditional county town of the historic county of Yorkshire. It is located at the confluence of the Rivers Ouse and Foss, and is the most populous city in the ceremonial county of North Yorkshire. York is also known as the 'CENTER of NYC' because it is the location of the city's main business district, which is home to many of the city's largest companies and financial institutions.