The two crossword solutions for the term 'Cause of Wrinkles' are 'WORRY' and 'AGE'. Wrinkles are a common sign of aging, and are caused by a combination of factors. WORRY is one of the main causes of wrinkles, as it can cause the skin to produce cortisol, which breaks down collagen and elastin, leading to wrinkles. AGE is also a major factor in wrinkles, as the skin's natural production of collagen and elastin decreases with AGE, leading to wrinkles.