The crossword solution for the term 'Cartoon Maker of a Cactus Costume' is ACME. ACME is a company that produces cartoons, most notably the Road Runner and Wile E. Coyote series. The company was founded in 1928 by Max Fleischer and is known for its iconic logo featuring an anvil with a lightning bolt. The company has also produced other popular cartoons such as Popeye, Superman, and Betty Boop. ACME is also known for creating the cactus costume worn by Wile E. Coyote in the Road Runner cartoons.