Caroline in the CITY is a popular American sitcom that aired from 1995 to 1999. The show follows the life of cartoonist Caroline Duffy, played by Lea Thompson, as she navigates her career and personal life in New York CITY. The crossword solution for the term 'Caroline in the CITY' is CITY, which is a four-letter word. This accurately reflects the setting of the show, as it takes place in a large metropolitan CITY.