The capital of Rhone is Lyon, which is a city in France. It is also known as Lyons, with five letters. Lyon is the third-largest city in France and is located in the east-central part of the country. It is known for its historical and architectural landmarks, such as the Basilica of Notre-Dame de Fourvière and the Roman amphitheater. Lyon is also a major center of business and culture, and is home to many universities and museums.