California's Santa ANA is a city in Orange County, located in the Los Angeles metropolitan area. It is the second most populous city in the county and the 57th most populous city in the United States. Santa Paula is a city in Ventura County, California. It was founded in 1872 and incorporated in 1902. It is located in the fertile Santa Clara River Valley of Southern California. Both cities are known for their agricultural production and have a rich history of Spanish and Mexican influence.