The term 'BOTHERS GREATLY' can be summarized by two crossword solutions: IRKS (4 letters) and EATSAT (6 letters). IRKS is a verb meaning to irritate or annoy someone, while EATSAT is an acronym for Electronic Automatic Test System for Applicants to Colleges. This system is used to evaluate college applicants based on their scores on standardized tests. Both of these solutions indicate that the term 'BOTHERS GREATLY' implies a feeling of annoyance or frustration.