The term 'BOTHERS BIG-TIME' can be broken down into three crossword solutions: IRKS (4 letters), EATSAT (6 letters), and GETSTO (6 letters). IRKS is a verb meaning to annoy or irritate, while EATSAT is an acronym for the Educational Aptitude Test, which is a standardized test used for college admissions. Finally, GETSTO is an acronym for the Graduate Record Examination, which is another standardized test used for graduate school admissions. All three of these terms can be used to describe a situation that bothers someone big-time, such as having to take multiple tests for college or graduate school admissions.