The crossword solution for the term BIG NUISANCE is PAIN. PAIN is an unpleasant sensation that can range from mild, localized discomfort to agony. It is a feeling of intense discomfort that can be physical, mental, or emotional in nature. PAIN can be caused by a variety of factors, including injury, disease, and psychological distress. PAIN can also be a sign of a serious medical condition, and should be evaluated by a doctor if it persists.