Being in charge of something means having the responsibility and authority to make decisions and direct the activities of others. The crossword solutions for this term are 'OVERSEE' (7 letters), 'HEAD' (4 letters), 'LEAD' (4 letters), 'MANAGE' (6 letters), 'RUN' (3 letters), 'OPERATE' (7 letters), and 'seeto' (5 letters). Each of these words implies a different level of responsibility and authority, with 'OVERSEE' being the highest and 'RUN' being the lowest.