Aspirin alternatives include ibuprofen and TYLENOL. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used to reduce pain, fever, and inflammation. It is available over the counter and in prescription strength. TYLENOL is an over-the-counter analgesic and antipyretic medication used to treat pain and fever. It is also available in prescription strength. Both ibuprofen and TYLENOL are effective alternatives to aspirin for treating pain and fever.