Artery blockages, also known as atherosclerosis, are a medical condition caused by the buildup of plaque in the arteries. This buildup can be caused by a variety of factors, including high cholesterol, smoking, and diabetes. CLOTS, which are five-letter words, are one of the most common causes of artery blockages. CLOTS are formed when blood cells stick together and form a mass that can block the flow of blood through the artery. If left untreated, these blockages can lead to serious health complications, such as heart attack or stroke.