Antagonise is a term used to describe the act of opposing or resisting someone or something. The crossword solutions for this term are ESTRANGE (8 letters), ALIENATE (8 letters), NEEDLE (6 letters), ANNOY (5 letters) and COUNTERACT (10 letters). ESTRANGE means to cause someone to become unsympathetic or indifferent, ALIENATE means to cause someone to become unfriendly or hostile, NEEDLE means to provoke or irritate someone, ANNOY means to cause someone to feel vexation or irritation and COUNTERACT means to oppose or COUNTERACT the effect of something. All of these words can be used to describe the act of antagonising someone or something.