The crossword solution for the term 'NEAREST and DEAREST' is a phrase that is often used to refer to someone's closest family members. It is usually used to express love and affection, and is often used in letters or cards to show appreciation for those closest to us. The phrase is also used to describe the people we are closest to, such as our parents, siblings, or other relatives. In addition, it can be used to refer to our closest friends, who are like family to us.