An Advil alternative is a medication that can be used to treat pain, fever, and inflammation. ANACIN, Motrin, TYLENOL, and ALEVE are all Advil alternatives that contain different active ingredients. ANACIN contains aspirin, caffeine, and an antacid, Motrin contains ibuprofen, TYLENOL contains acetaminophen, and ALEVE contains naproxen sodium. All of these medications can be used to treat pain, fever, and inflammation, but they should be taken as directed by a doctor or pharmacist.