Anacin is an over-the-counter pain reliever that was first introduced in the early 1900s. It is manufactured by BAYER, a German pharmaceutical and life sciences company. Anacin contains a combination of aspirin and caffeine, which helps to reduce pain and inflammation. TYLENOL and ALEVE are two other popular over-the-counter pain relievers that are also manufactured by BAYER. TYLENOL contains acetaminophen, while ALEVE contains naproxen sodium. All three medications are effective at relieving pain and inflammation, but Anacin is the only one that contains both aspirin and caffeine.