The term 'YOUR LARGEST ORGAN' can be solved by the crossword solution 'SKIN', which is a four letter word. The SKIN is the largest organ in the human body, covering the entire surface of the body and weighing around 8 pounds. It is made up of three layers: the epidermis, dermis, and subcutaneous layer. The SKIN serves many important functions, such as protection from the environment, regulation of body temperature, and sensation.