The term 'What's up, ___?' can be completed with the answers DOC (3 letters), SKY (3 letters), DAWG (4 letters), NORTH (5 letters), SKIES (5 letters), and QUEPASA (7 letters). The answer DOC is an abbreviation for 'DOCTOR, ' which is a title given to someone who has earned a degree in medicine. SKY is a noun that refers to the atmosphere or expanse of space that seems to surround the earth. DAWG is a slang term for 'FRIEND' or 'PAL.' NORTH is one of the four cardinal directions. SKIES is a plural form of the noun 'SKY, ' which refers to the atmosphere or expanse of space that seems to surround the earth. QUEPASA is a Spanish phrase meaning 'what's happening?'