What's Eating Gilbert Grape is a 1993 American drama film directed by Lasse Hallström and starring Johnny Depp, Juliette Lewis, and Leonardo DiCaprio. The film follows the story of Gilbert Grape (Depp), a young man living in a small town with his family, including his mentally disabled brother Arnie (DiCaprio). The crossword solution for this term is 'PARASITE', which is an apt description of the film's main antagonist, a woman named Betty Carver (Lewis) who moves into the Grape family's home and begins to disrupt their lives.