The term 'What Pandora Loosed' is a reference to Greek mythology. Pandora was the first woman created by the gods, and when she opened a box given to her by Zeus, all of the evils of the world were released. This phrase is used to refer to the idea that once something bad has been unleashed, it cannot be taken back. The crossword solution for this term is 'EVILS', which is a five-letter word meaning 'bad or harmful things'.