The crossword solution for the term VILLA ___, TIVOLI is DESTE, which is a five-letter word. DESTE is an Italian word meaning 'from the south'. It is often used to refer to the southern region of Italy, which is known for its beautiful villas and gardens. Tivoli is a town in the Lazio region of Italy, located south of Rome. It is home to many villas, including Villa d'Este, a 16th century villa with beautiful gardens and fountains.