The term Vatican Venue is composed of two crossword solutions: Rome (4 letters) and CHAPEL (6 letters). Rome is the capital of Italy and is one of the oldest cities in the world, having been founded in 753 BC. It is home to many iconic landmarks, including the Colosseum and the Pantheon. The Vatican City, an independent city-state located within Rome, is the headquarters of the Roman Catholic Church and the home of the Pope. The CHAPEL, located within the Vatican City, is a place of worship and prayer for the Catholic Church. It is also the site of many important religious ceremonies, such as papal conclaves and canonizations.