The term Vatican-based is related to the Papal, which is a five letter word. The Vatican is the headquarters of the Roman Catholic Church and the Pope is its leader. The Vatican is located in Rome, Italy and is home to many important religious sites, such as St. Peter's Basilica and the Sistine Chapel. The Vatican also houses the world's largest library, the Vatican Library, and is the center of the Catholic faith. The Pope is the spiritual leader of the Catholic Church and is elected by the College of Cardinals. The Pope is responsible for making decisions on matters of faith and doctrine, and is the head of the Catholic Church.