Ed ASNER is a five-letter answer to the crossword clue 'Up Voice Actor'. He is an American actor, voice actor, and comedian who has been in the entertainment industry since the 1950s. He is best known for his role as Lou Grant on both The Mary Tyler Moore Show and its spin-off series, Lou Grant. He also voiced the character of Carl Fredricksen in the 2009 Pixar film Up. ASNER has won seven Emmy Awards and has been nominated for 16 more.