Up and running is a phrase used to describe a system or process that is functioning properly and is ready for use. The two crossword solutions, ALIVE (5 letters) and ONSTREAM (8 letters), are related to this phrase and can be used to describe the same concept. ALIVE is used to describe something that is active and functioning, while ONSTREAM is used to describe something that is in operation and available for use. Together, these two words can be used to describe a system or process that is up and running.