The term 'Up Against It' can be summarized by four crossword solutions: DESPERATE (9 letters), EMBATTLED (9 letters), Inafix (6 letters), and On the Ropes (10 letters). DESPERATE implies a state of extreme need or distress, while EMBATTLED suggests being in a state of conflict or difficulty. Inafix implies being stuck in a difficult situation, and On the Ropes implies being in a weakened or vulnerable position. All four words suggest a situation of difficulty or hardship.