The term UNSEX refers to the process of changing the sex of an animal or person. This can be done through a variety of methods, including GELD (4 letters), which is the removal of the testicles from a male animal; SPAY (4 letters), which is the removal of the ovaries and uterus from a female animal; ALTER (5 letters), which is the surgical alteration of the reproductive organs; CASTRATE (8 letters), which is the removal of the testicles from a male animal; MUTILATE (8 letters), which is the intentional disfigurement of the body; and CHANGE (6 letters), which is the alteration of the physical characteristics of a person or animal.