UNO AND DUE is a term used to refer to the two main Italian political parties, the Democratic Party (Partito Democratico, or PD) and the Five Star Movement (Movimento Cinque Stelle, or M5S). The term UNO AND DUE is derived from the first letters of the two parties' names, U for the PD and D for the M5S. The answer to the crossword puzzle is TRE, which stands for the third major Italian political party, Forza Italia (FI).