The crossword solution for the term TWO PILLS, E.G. is DOSE, which is a four-letter word. DOSE is a noun that refers to the amount of a medicine, drug, or vitamin that is taken at any one time. It is also used to refer to the strength or concentration of a substance, such as a chemical or radiation. In this context, it can be used to refer to two pills, e.g. two pills of the same medication taken at the same time.