The term 'Twisted Guy' can be summed up with the crossword solution 'SICKO, ' which is a five-letter word. The term 'Twisted Guy' is often used to describe someone who is mentally unstable or has a distorted view of reality. This person may have a tendency to act in a way that is considered socially unacceptable or immoral. They may also have a distorted sense of right and wrong, and may be prone to violent behavior.