The crossword solution for the term 'Tuscany Cathedral City' is Siena, a five letter word. Siena is a city in the Tuscany region of Italy, located about an hour south of Florence. It is known for its medieval architecture and art, and is home to the famous Siena Cathedral, a Gothic-style cathedral built between 1215 and 1263. The cathedral is a UNESCO World Heritage Site and is one of the most visited tourist attractions in the region.