Turn loose is a phrase that means to set something FREE, usually from a physical restraint. Unscrew, RELEASE, UNLEASH, UNTIE, FREE, and letgo are all synonyms for this phrase. Unscrew means to remove a screw or screws from an object. RELEASE means to set something FREE from a physical restraint. UNLEASH means to set something FREE from a metaphorical restraint. UNTIE means to loosen a knot or knots. FREE means to set something FREE from a physical or metaphorical restraint. Letgo means to let something go, usually from one's grasp.