The crossword solution for the term 'Trouble, with 'AT'' is GNAW, which is a four-letter word. GNAW is a verb that means to bite or chew on something persistently, usually with the teeth. It can also be used figuratively to describe a situation where someone is persistently worrying or stressing about something. Therefore, the phrase 'Trouble, with 'AT'' can be interpreted as a situation where someone is persistently worrying or stressing about something.