The term 'Tree of Knowledge Garden' is a reference to the biblical story of Adam and Eve in the Garden of EDEN. In the story, God placed a tree in the Garden of EDEN that was known as the Tree of Knowledge of Good and Evil. Eating from this tree was forbidden by God, but Adam and Eve disobeyed and ate from it, leading to their expulsion from the Garden of EDEN. The crossword solution for this term is EDEN, which is the name of the Garden of EDEN in the Bible.