The crossword solution for the term 'Treat, as a sprain' is ICE. This acronym stands for 'ICE, Compression, and Elevation, ' which are the three steps recommended for treating a sprain. ICE should be applied to the affected area for 15-20 minutes at a time, several times a day. Compression should be applied with an elastic bandage to reduce swelling. Finally, elevation of the affected area can help reduce swelling and pain.