Totally screw up is a phrase used to describe a situation where something has gone wrong, usually due to someone's mistake. The crossword solutions for this phrase are BUNGLE (6 letters), RUIN (4 letters), MISADD (6 letters), and BLOWIT (6 letters). BUNGLE means to make a mess of something, RUIN means to destroy or damage something, misadd means to make an incorrect addition, and blowit means to make a mistake. All of these words can be used to describe a situation where someone has totally screwed up.