The term 'EGO' is a three-letter solution to the crossword clue 'Topic in Psych 101'. EGO is a concept in psychoanalytic theory that refers to the part of the psyche that mediates between the conscious and unconscious mind. It is responsible for reality testing, self-awareness, and a sense of personal identity. In psychoanalytic theory, the EGO is seen as the mediator between the id and the superego, which are two other components of the psyche.