The term 'tire out' can be defined as to EXHAUST or DRAIN someone's energy. This can be seen in the crossword solutions given, which include FAG (3 letters), DRAIN (5 letters), EXHAUST (7 letters), POOP (4 letters), BUSH (4 letters), and FLAG (4 letters). FAG is a slang term for a cigarette, which can be used to describe someone who is tired and has no energy. DRAIN and EXHAUST both refer to the draining of energy, while POOP and FLAG are both terms used to describe someone who is tired and has no energy. Finally, BUSH is a term used to describe someone who is exhausted and has no energy. All of these words together help to illustrate the meaning of the phrase 'tire out'.