The term 'Thumbs' Opposites' refers to the opposite ends of the hands, which are the thumbs and the pinkies. The answer to this crossword puzzle is 'PINKIES, ' which is a seven-letter word. The pinkies are the smallest fingers on the hands and are located at the outermost edges of the hands. They are used for gripping and manipulating objects, and are often used in combination with the thumbs to perform tasks such as typing or playing musical instruments.