The Hoosier State is the nickname for the U.S. state of Indiana. Indiana is located in the Midwestern region of the United States and is the 16th most populous state in the country. The origin of the term 'Hoosier' is unknown, but it is believed to have come from a term used by settlers in the early 1800s. Indiana is known for its agricultural production, manufacturing, and sports teams. It is also home to several universities and colleges, including Purdue University and Indiana University.