The Gateway City of Texas is Laredo, a city located in Webb County, Texas. It is the county seat of Webb County and is located on the north bank of the Rio Grande, across from Nuevo Laredo, Tamaulipas, Mexico. Laredo is the largest inland port in the United States and is the largest city in South Texas. It has a population of over 250, 000 people and is a major hub for international trade. It is also home to several universities and colleges, making it an important educational center in the region.