The 'E' in homes is the answer to the crossword clue 'ERIE' (4 letters). The 'E' in homes is a reference to the Erie Canal, which is a 363-mile long canal connecting the Hudson River to Lake Erie. It was built in the early 19th century and was an important part of the development of the United States. It allowed for the transportation of goods from the Midwest to the East Coast, and it also helped to stimulate the economy of the region.