Taste bud setting is a term used to describe the way in which taste buds are arranged on the TONGUE. It is the pattern of taste buds that determines how we perceive different flavors. The crossword solutions for the term 'taste bud setting' are TONGUE, which has 6 letters. The TONGUE is the organ responsible for tasting food and drinks, and it is covered with thousands of tiny bumps called papillae, which contain the taste buds. Taste buds are specialized cells that detect the five basic tastes: sweet, sour, salty, bitter, and umami. The arrangement of these taste buds on the TONGUE helps us to distinguish between different flavors.