Take issue is a phrase that means to DISAGREE or ARGUE with someone. It can also mean to OBJECT to something. The crossword solutions for this phrase are DISAGREE (8 letters), ARGUE (5 letters), and OBJECT (6 letters). All three of these words have similar meanings, but they can be used in different contexts. DISAGREE is the most general term, and it can be used to describe any kind of disagreement. ARGUE implies a more heated discussion, while OBJECT implies a more formal opposition.