The answer to the crossword for the term 'Subject of a Louisville Museum' is ALI, which stands for the boxer Muhammad Ali. Muhammad Ali was an American professional boxer and activist who is widely regarded as one of the most significant and celebrated sports figures of the 20th century. He was born in Louisville, Kentucky, and a museum dedicated to his life and legacy is located there. The Muhammad Ali Center is a multicultural center with an award-winning museum that celebrates the life and legacy of Muhammad Ali. It includes interactive exhibits, films, and educational programs that explore the core principles of Ali's life: Confidence, Conviction, Dedication, Respect, and Giving.